Myocardial imaging using 11C-CoQ10 with positron emission tomography.

نویسندگان

  • Y Miura
  • Y Kagaya
  • E Nozaki
  • N Ishide
  • Y Maruyama
  • T Takishima
  • T Takahashi
  • K Ishiwata
  • S Watanuki
  • T Ido
چکیده

The potential of 11C-labeled coenzyme Q10(CoQ10) as a myocardial imaging tracer was explored with positron emission tomography (PET). Serial myocardial imaging studies were performed using 11C-CoQ10, 45Ti-diethylenetriaminepentaacetic acid (45Ti-DTPA), and 2-deoxy-2-[18F]fluoro-D-mannose (18FDM) in the same dog. Cross sectional images of the heart with 11C-CoQ10 showed relatively high radioactivity in the blood pool, when compared with images taken with 18FDM. However, when the blood spillover of radioactivity is adequately corrected with 45Ti-DTPA data, it was found that 11C-CoQ10 accumulated in the myocardium with time.

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عنوان ژورنال:
  • International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology

دوره 14 1  شماره 

صفحات  -

تاریخ انتشار 1987